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Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy

7 Jun 2024

Abstract excerpt

The landscape of hepatitis B virus (HBV) integration in the plasma cell-free DNA (cfDNA) of HBV-infected patients with different stages of liver diseases [chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC)] remains unclear. In this study, we developed an improved strategy for detecting HBV DNA integration in plasma cfDNA, based on DNA probe capture and next-generation sequencing....

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PMID: 38852920
DOI: 10.1016/j.virs.2024.06.003

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