The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients.

doi:10.1158/1078-0432.CCR-21-0002

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The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2021

Zheng Bo, Liu Xiao-Long, Fan Rong, Bai Jian, Wen Hao, Du Lu-Tao, Jiang Guo-Qing, Wang Chun-Ying, Fan Xiao-Tang, Ye Yi-Nong, Qian Yun-Song, Wang Ying-Chao, Liu Gao-Jing, Deng Guo-Hong, Shen Feng, Hu He-Ping, Wang Hui, Zhang Qing-Zheng, Ru Lan-Lan, Zhang Jing, Gao Yan-Hang, Xia Jie, Yan Hua-Dong, Liang Min-Feng, Yu Yan-Long, Sun Fu-Ming, Gao Yu-Jing, Sun Jian, Zhong Chun-Xiu, Wang Yin, Kong Fei, Chen Jin-Ming, Zheng Dan, Yang Yuan, Wang Chuan-Xin, Wu Lin, Hou Jin-Lin, Liu Jing-Feng, Wang Hong-Yang, Chen Lei

Abstract excerpt

PURPOSE: Intratumoral hepatitis B virus (HBV) integrations and mutations are related to hepatocellular carcinoma (HCC) progression. Circulating cell-free DNA (cfDNA) has shown itself as a powerful noninvasive biomarker for cancer. However, the HBV integration and mutation landscape on cfDNA remains unclear. EXPERIMENTAL DESIGN: A cSMART (Circulating Single-Molecule Amplification and Resequencing Technology)-based...

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PMID: 33947693
DOI: 10.1158/1078-0432.CCR-21-0002

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