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Exploring the HLA complex in autoimmunity: From the risk haplotypes to the modulation of expression.

Clinical immunology (Orlando, Fla.) - 1 Aug 2024

Sartoris Silvia, Del Pozzo Giovanna

Abstract excerpt

The genes mapping at the HLA region show high density, strong linkage disequilibrium and high polymorphism, which affect the association of HLA class I and class II genes with autoimmunity. We focused on the HLA haplotypes, genomic structures consisting of an array of specific alleles showing some degrees of genetic association with different autoimmune disorders. GWASs in many pathologies have identified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38851519
DOI: 10.1016/j.clim.2024.110266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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