Article
Tentonin 3 is a pore-forming subunit of a slow inactivation mechanosensitive channel.
Cell reports - 25 Jun 2024
Pak Sungmin, Ryu Hyunil, Lim Sujin, Nguyen Thien-Luan, Yang Sungwook, Kang Sumin, Yu Yeon Gyu, Woo Junhyuk, Kim Chanjin, Fenollar-Ferrer Cristina, Wood John N, Lee Mi-Ock, Hong Gyu-Sang, Han Kyungreem, Kim Tae Song, Oh Uhtaek
Abstract excerpt
Mechanically activating (MA) channels transduce numerous physiological functions. Tentonin 3/TMEM150C (TTN3) confers MA currents with slow inactivation kinetics in somato- and barosensory neurons. However, questions were raised about its role as a Piezo1 regulator and its potential as a channel pore. Here, we demonstrate that purified TTN3 proteins incorporated into the lipid bilayer displayed spontaneous and...
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