Article
Somatic mutations and T-cell clonality in patients with immunodeficiency.
Haematologica - 1 Dec 2020
Savola Paula, Martelius Timi, Kankainen Matti, Huuhtanen Jani, Lundgren Sofie, Koski Yrjö, Eldfors Samuli, Kelkka Tiina, Keränen Mikko A I, Ellonen Pekka, Kovanen Panu E, Kytölä Soili, Saarela Janna, Lähdesmäki Harri, Seppänen Mikko R J, Mustjoki Satu
Abstract excerpt
Common variable immunodeficiency and other late-onset immunodeficiencies often co-manifest with autoimmunity and lymphoproliferation. The pathogenesis of most cases is elusive, as only a minor subset harbors known monogenic germline causes. The involvement of both B and T cells is however implicated. To study whether somatic mutations in CD4+ and CD8+ T cells associate with immunodeficiency, we recruited 17...
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