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Article

Understanding the immunological impact of the human mutation explosion.

Trends in immunology - 1 Mar 2013

Andrews T D, Sjollema G, Goodnow C C

Abstract excerpt

The recent development of human exome sequencing technology has revealed that our immune system is riddled with more genetic defects than anyone imagined. As a legacy of the recent human population explosion, we each inherit hundreds of rare mutations that alter the sequence of proteins. This mutation load is ten times higher than that induced by experimental treatment of mice by ethylnitrosourea; a high fraction...

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PMID: 23333204
DOI: 10.1016/j.it.2012.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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