Article
Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN.
Cancer cell - 8 Sept 2009
Fridlender Zvi G, Sun Jing, Kim Samuel, Kapoor Veena, Cheng Guanjun, Ling Leona, Worthen G Scott, Albelda Steven M
Abstract excerpt
TGF-beta blockade significantly slows tumor growth through many mechanisms, including activation of CD8(+) T cells and macrophages. Here, we show that TGF-beta blockade also increases neutrophil-attracting chemokines, resulting in an influx of CD11b(+)/Ly6G(+) tumor-associated neutrophils (TANs) that are hypersegmented, more cytotoxic to tumor cells, and express higher levels of proinflammatory cytokines....
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