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Article

Loss of the proteasomal deubiquitinase USP14 induces growth defects and a senescence phenotype in colorectal cancer cells.

Scientific reports - 6 Jun 2024

Gubat Johannes, Sjöstrand Linda, Selvaraju Karthik, Telli Kübra, D'Arcy Pádraig

Abstract excerpt

The proteasome-associated deubiquitinase USP14 is a potential drug target. Using an inducible USP14 knockout system in colon cancer cells, we found that USP14 depletion impedes cellular proliferation, induces cell cycle arrest, and leads to a senescence-like phenotype. Transcriptomic analysis revealed altered gene expression related to cell division and cellular differentiation. USP14 knockout cells also...

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Identifiers

PMID: 38844605
DOI: 10.1038/s41598-024-63791-5
PMCID: PMC11156967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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