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Article

Structural Basis for Stepwise Substrate Transport and Disease Phenotypic Heterogeneity of the Mitochondrial ADP/ATP Carrier.

Journal of chemical information and modeling - 10 Aug 2026

Yao Shihao, He Xiao, Yi Qiuzi, Zhang Qinghai, Guan Min-Xin

Abstract excerpt

The mitochondrial ADP/ATP carrier (AAC) is essential for cellular energy metabolism and responsible for exchanging ADP for ATP across the inner mitochondrial membrane. However, the precise molecular determinants of substrate binding and the mechanisms underlying the phenotypic heterogeneity of AAC-related diseases remain poorly understood. Here, we combined AlphaFold3 predictions, molecular dynamics simulations,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42308345
DOI: 10.1021/acs.jcim.6c01006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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