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Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients

5 Jun 2024

Abstract excerpt

Synucleinopathies such as Parkinson's disease (PD) are defined by the accumulation and aggregation of the α-synuclein protein in neurons, glia and other tissues. We have previously shown that destabilization of α-synuclein tetramers is associated with familial PD due to SNCA mutations and demonstrated brain-region specific alterations of α-synuclein multimers in sporadic PD patients following the classical Braak...

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PMID: 38839930
DOI: 10.1038/s44321-024-00083-5

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