Article
Alpha-synuclein dimerization in erythrocytes of patients with genetic and non-genetic forms of Parkinson's Disease.
Neuroscience letters - 13 Apr 2018
Papagiannakis Nikolaos, Koros Christos, Stamelou Maria, Simitsi Athina-Maria, Maniati Matina, Antonelou Roubina, Papadimitriou Dimitra, Dermentzaki Georgia, Moraitou Marina, Michelakakis Helen, Stefanis Leonidas
Abstract excerpt
BACKGROUND: Variations of α-synuclein levels or species have been reported in Parkinson's Disease (PD). There has been little systematic examination of erythrocytes, a rich source of α-synuclein. METHODS: Erythrocyte membranes were obtained from PD patients (mutation carriers in the α-synuclein gene (A53T-PD) and glucocerebrosidase gene (GBA-PD) (n=18 each), and patients without known mutations (GU-PD, n=56)),...
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