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Article

A targetable PRR11-DHODH axis drives ferroptosis- and temozolomide-resistance in glioblastoma

30 May 2024

Abstract excerpt

Temozolomide (TMZ) is a widely utilized chemotherapy treatment for patients with glioblastoma (GBM), although drug resistance constitutes a major therapeutic hurdle. Emerging evidence suggests that ferroptosis-mediated therapy could offer an appropriate alternative treatment option against cancer cells that are resistant to certain drugs. However, recurrent gliomas display robust ferroptosis resistance, although...

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Share to Epigenetics and DNA Methylation
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PMID: 38838551
DOI: 10.1016/j.redox.2024.103220

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