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ALDH1-Mediated Autophagy Sensitizes Glioblastoma Cells to Ferroptosis

12 Dec 2022

Abstract excerpt

The fatal clinical course of human glioblastoma (GBM) despite aggressive adjuvant therapies is due to high rates of recurrent tumor growth driven by tumor cells with stem-cell characteristics (glioma stem cells, GSCs). The aldehyde dehydrogenase 1 (ALDH1) family of enzymes has been shown to be a biomarker for GSCs, and ALDH1 seems to be involved in the biological processes causing therapy resistance. Ferroptosis...

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PMID: 36552781
DOI: 10.3390/cells11244015

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