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Article

A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis

23 Jun 2020

Abstract excerpt

Temozolomide (TMZ) is the first-line chemotherapy drug that has been used to treat glioma for over a decade, but the benefits are limited by half of the treated patients who acquired resistance. Studies have shown that glioma TMZ resistance is a complex process with multiple factors, which has not been fully elucidated. Ferroptosis, which is a new type of cell death discovered in recent years, has been reported...

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PMID: 32656078
DOI: 10.3389/fonc.2020.00897

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