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BATF-dependent Th17 cells act through the IL-23R pathway to promote prostate adenocarcinoma initiation and progression

1 Jun 2024

Abstract excerpt

BACKGROUND: The role of Th17 cells in prostate cancer is not fully understood. The transcription factor BATF controls the differentiation of Th17 cells. Mice deficient in Batf do not produce Th17 cells. METHODS: In this study, we aimed to characterize the role of Batf-dependent Th17 cells in prostate cancer by crossbreeding Batf knockout mice with mice conditionally mutant for Pten. RESULTS: We found that Batf...

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PMID: 38833676
DOI: 10.1093/jnci/djae120

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