Article
Role of IL-23 signaling in the progression of premalignant oral lesions to cancer.
PloS one - 1 Jan 2018
Caughron Blaine, Yang Yi, Young M Rita I
Abstract excerpt
Mice bearing carcinogen-induced premalignant oral lesions were previously shown to have a pro-inflammatory phenotype, which is replaced with an immune inhibitory phenotype as lesions progress to cancer. Since Th17 cells are prominent at the premalignant lesion state and their levels are supported by IL-23, studies used mice that were IL-23 receptor deficient (IL-23R KO) to determine the requirement for IL-23...
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