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Article

Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2018

Fuseini Hubaida, Yung Jeffrey A, Cephus Jacqueline Yvonne, Zhang Jian, Goleniewska Kasia, Polosukhin Vasiliy V, Peebles R Stokes, Newcomb Dawn C

Abstract excerpt

As adults, women are twice as likely as men to have asthma; however, the mechanisms explaining this sexual dimorphism remain unclear. Increased type 2 cytokines and/or IL-17A, leading to increased airway eosinophils and neutrophils, respectively, are associated with asthma. Previous studies showed that testosterone, signaling through the androgen receptor (AR), decreased Th2-mediated allergic inflammation and...

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Identifiers

PMID: 30127088
DOI: 10.4049/jimmunol.1800293
PMCID: PMC6143420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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