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Article

[Epigenetic dysregulation and emerging treatment strategies in myelodysplastic syndromes].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2024

Kunimoto Hiroyoshi

Abstract excerpt

The epigenome regulates transcription of target genes through DNA methylation- or histone methylation/acetylation/phosphorylation/ubiquitination-mediated alteration of genomic function or chromatin conformation. Recent genomic studies have shown that multiple genes encoding epigenetic regulators are frequently and recurrently mutated in MDS, suggesting that epigenetic dysregulation is significantly associated...

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PMID: 38825515
DOI: 10.11406/rinketsu.65.362

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