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Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus

31 Mar 2025

Abstract excerpt

The global outbreak of monkeypox virus (MPXV), combined with the termination of smallpox vaccination and the lack of specific antiviral treatments, raises increasing concerns. The surface proteins M1R and B6R of MPXV are crucial for virus transmission and serve as key targets for vaccine development. In this study, a panel of human antibodies targeting M1R and B6R is isolated from a human antibody library using...

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PMID: 40164599
DOI: 10.1038/s41467-025-58180-z

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