Article
Liver-on-chip model and application in predictive genotoxicity and mutagenicity of drugs.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2000
Kopp B, Khawam A, Di Perna K, Lenart D, Vinette M, Silva R, Zanoni T B, Rore C, Guenigault G, Richardson E, Kostrzewski T, Boswell A, Van P, Valentine Iii C, Salk J, Hamel A
Abstract excerpt
Currently, there is no test system, whether in vitro or in vivo, capable of examining all endpoints required for genotoxicity evaluation used in pre-clinical drug safety assessment. The objective of this study was to develop a model which could assess all the required endpoints and possesses robust human metabolic activity, that could be used in a streamlined, animal-free manner. Liver-on-chip (LOC) models have...
Topics
- Humans
- Hepatocytes
- Mutagens
- Micronucleus Tests
- Mutagenicity Tests
- Liver
- Lab-On-A-Chip Devices
- DNA Damage
- Comet Assay
- Cyclophosphamide