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Occupational Pesticide Exposure in Parkinson’s Disease Related to GBA and LRRK2 Variants

28 May 2024

Abstract excerpt

Background: The penetrance of common genetic risk variants for Parkinson's disease (PD) is low. Pesticide exposure increases PD risk, but how exposure affects penetrance is not well understood. Objective: To determine the relationship between occupational pesticide exposure and PD in people with LRRK2 and GBA risk variants. Methods: Participants of the Parkinson's Progression Markers Initiative (PPMI) with a...

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PMID: 38820021
DOI: 10.3233/jpd-240015

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