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Article

Dual-Risk axis: GBA1 mutations and occupational pesticide exposure in Parkinson's disease.

Journal of Parkinson's disease - 1 May 2026

Üstündağ Zeynep Hilal, Özçelik Hazal, Koker Ipek, Özkan Pınar, Kar İrem, Ozmutlu Buse Elitas, Mutlu Elif İpek Gençer, Yildiz Gunal Damla, Yekedüz Merve Koç, Eminoğlu Fatma Tuba, Akbostancı M Cenk, Yilmaz Rezzak

Abstract excerpt

BackgroundOccupational pesticide (OcP) exposure and pathogenic GBA1 variants are established risk factors for Parkinson's disease (PD). However, whether they interact to influence disease onset or severity remains uncertain.ObjectiveTo determine the prevalence of OcP exposure and other lifestyle risks in relation to GBA1 status and their interactions on age of onset (AOO) and clinical scores in a...

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Identifiers

PMID: 41549707
DOI: 10.1177/1877718X251412233
PMCID: PMC13347593

Genes

GBA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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