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miRNA sequencing reveals miRNA-4508 from peripheral blood lymphocytes as potential diagnostic biomarker for silica-related pulmonary fibrosis: A multistage study.

Respirology (Carlton, Vic.) - 1 May 2020

Chu Minjie, Wu Shuangshuang, Wang Wei, Mao Liping, Yu Yuhui, Jiang Liying, Yuan Weiyan, Zhang Mingjiong, Sang Lingli, Huang Qiqing, Tian Tian, Han Lei, Zhuang Xun, Zhang Zuo-Feng, Wu Jianqing

Abstract excerpt

BACKGROUND AND OBJECTIVE: This study aimed to identify miRNA as potential diagnostic biomarkers for silica-related pulmonary fibrosis (SPF). METHODS: We first performed a comprehensive miRNA-seq screening in PBL of eight subjects exposed to silica dust (four individuals with SPF and four healthy controls). The promising miRNA were then evaluated in the first-stage validation using an independent GEO data set...

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PMID: 31663225
DOI: 10.1111/resp.13714

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