Article
The unc-45 gene of Caenorhabditis elegans is an essential muscle-affecting gene with maternal expression.
Genetics - 1 Oct 1990
Venolia L, Waterston R H
Abstract excerpt
We have isolated three novel alleles of the unc-45 locus in C. elegans, that are recessive lethals. Two of these alleles, when homozygous, result in a nearly total loss of muscle contraction with a concomitant arrest of development and a displacement of muscle cells. The third allele is similar, but showed maternal rescue by a wild-type allele. All previously identified unc-45 alleles were temperature sensitive...
Topics
- Alleles
- Animals
- Caenorhabditis
- Crosses, Genetic
- Female
- Gene Expression Regulation
- Genes, Lethal
- Genes, Recessive
- Male
- Muscles
- Mutation
- Myosins