Article
Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Aug 2024
Santanasto Adam J, Acharya Sandeep, Wojczynski Mary K, Cvejkus Ryan K, Lin Shiow, Brent Michael R, Anema Jason A, Wang Lihua, Thyagarajan Bharat, Christensen Kaare, Daw E Warwick, Zmuda Joseph M
Abstract excerpt
BACKGROUND: Grip strength is a robust indicator of overall health, is moderately heritable, and predicts longevity in older adults. METHODS: Using genome-wide linkage analysis, we identified a novel locus on chromosome 18p (mega-basepair region: 3.4-4.0) linked to grip strength in 3 755 individuals from 582 families aged 64 ± 12 years (range 30-110 years; 55% women). There were 26 families that contributed to the...
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