Article
Rare genetic variants impact muscle strength.
Nature communications - 10 Jun 2023
Huang Yunfeng, Bodnar Dora, Chen Chia-Yen, Sanchez-Andrade Gabriela, Sanderson Mark, Shi Jun, Meilleur Katherine G, Hurles Matthew E, Gerety Sebastian S, Tsai Ellen A, Runz Heiko
Abstract excerpt
Muscle strength is highly heritable and predictive for multiple adverse health outcomes including mortality. Here, we present a rare protein-coding variant association study in 340,319 individuals for hand grip strength, a proxy measure of muscle strength. We show that the exome-wide burden of rare protein-truncating and damaging missense variants is associated with a reduction in hand grip strength. We identify...
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