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Article

A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4.

PLoS genetics - 1 Feb 2016

Masyukova Svetlana V, Landis Dawn E, Henke Scott J, Williams Corey L, Pieczynski Jay N, Roszczynialski Kelly N, Covington Jannese E, Malarkey Erik B, Yoder Bradley K

Abstract excerpt

Nephronophthisis (NPHP) is a ciliopathy in which genetic modifiers may underlie the variable penetrance of clinical features. To identify modifiers, a screen was conducted on C. elegans nphp-4(tm925) mutants. Mutations in ten loci exacerbating nphp-4(tm925) ciliary defects were obtained. Four loci have been identified, three of which are established ciliopathy genes mks-1, mks-2, and mks-5. The fourth allele...

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Share to Caenorhabditis elegans Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26863025
DOI: 10.1371/journal.pgen.1005841
PMCID: PMC4749664

Genes

OSM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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