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Article

GGT1 is a SNP eQTL gene involved in STAT3 activation and associated with the development of Post-ERCP pancreatitis.

Scientific reports - 28 May 2024

Furukawa Ryutaro, Kuwatani Masaki, Jiang Jing-Jing, Tanaka Yuki, Hasebe Rie, Murakami Kaoru, Tanaka Kumiko, Hirata Noriyuki, Ohki Izuru, Takahashi Ikuko, Yamasaki Takeshi, Shinohara Yuta, Nozawa Shunichiro, Hojyo Shintaro, Kubota Shimpei I, Hashimoto Shigeru, Hirano Satoshi, Sakamoto Naoya, Murakami Masaaki

Abstract excerpt

Post-ERCP pancreatitis (PEP) is an acute pancreatitis caused by endoscopic-retrograde-cholangiopancreatography (ERCP). About 10% of patients develop PEP after ERCP. Here we show that gamma-glutamyltransferase 1 (GGT1)-SNP rs5751901 is an eQTL in pancreatic cells associated with PEP and a positive regulator of the IL-6 amplifier. More PEP patients had the GGT1 SNP rs5751901 risk allele (C) than that of non-PEP...

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Share to Cytokine Receptor gp130
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Source

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Identifiers

PMID: 38806529
DOI: 10.1038/s41598-024-60312-2
PMCID: PMC11133343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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