Article
Pooling-based genome-wide association study implicates gamma-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2010
Diergaarde Brenda, Brand Randall, Lamb Janette, Cheong Soo Yeon, Stello Kim, Barmada M Michael, Feingold Eleanor, Whitcomb David C
Abstract excerpt
BACKGROUND/AIMS: Knowledge regarding genetic factors that influence pancreatic cancer risk is currently limited. To identify novel pancreatic cancer susceptibility loci, we conducted a two-stage genome-wide association study. METHODS: The Affymetrix Genome-Wide Human SNP Array 6.0 and DNA pooling were used in the screening stage. Twenty-six single-nucleotide polymorphisms (SNPs) were selected for follow-up. These...
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