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Article

Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.

Oncotarget - 10 May 2016

Zhou Fei, Cheng Lei, Qiu Li-Xin, Wang Meng-Yun, Li Jin, Sun Meng-Hong, Yang Ya-Jun, Wang Jiu-Cun, Jin Li, Wang Ya-Nong, Wei Qing-Yi

Abstract excerpt

The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially functional single nucleotide polymorphisms (SNPs) of four essential genes in the pathway and GCa risk in a study of 1,125 GCa cases and 1,221 cancer-free controls. We found that a significant higher GCa risk was associated with...

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Source

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Identifiers

PMID: 27049718
DOI: 10.18632/oncotarget.8492
PMCID: PMC5053713

Genes

STAT3
JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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