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Article

Viral Genomic Variation and the Severity of Genital Herpes Simplex Virus-2 Infection as Quantified by Shedding Rate: A Viral Genome-Wide Association Study.

The Journal of infectious diseases - 16 Dec 2024

Casto Amanda M, Song Hoseung, Xie Hong, Selke Stacy, Roychoudhury Pavitra, Wu Michael C, Wald Anna, Greninger Alexander L, Johnston Christine

Abstract excerpt

BACKGROUND: The clinical severity of genital herpes simplex virus-2 (HSV-2) infection varies widely among infected persons with some experiencing frequent genital lesions while others are asymptomatic. The viral genital shedding rate is closely associated with, and has been established as, a surrogate marker of clinical severity. METHODS: To assess the relationship between viral genetics and shedding, we...

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Identifiers

PMID: 38805234
DOI: 10.1093/infdis/jiae283
PMCID: PMC11646587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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