Article
Highly conserved intragenic HSV-2 sequences: Results from next-generation sequencing of HSV-2 UL and US regions from genital swabs collected from 3 continents.
Virology - 1 Oct 2017
Johnston Christine, Magaret Amalia, Roychoudhury Pavitra, Greninger Alexander L, Cheng Anqi, Diem Kurt, Fitzgibbon Matthew P, Huang Meei-Li, Selke Stacy, Lingappa Jairam R, Celum Connie, Jerome Keith R, Wald Anna, Koelle David M
Abstract excerpt
INTRODUCTION: Understanding the variability in circulating herpes simplex virus type 2 (HSV-2) genomic sequences is critical to the development of HSV-2 vaccines. METHODS: Genital lesion swabs containing ≥ 107log10 copies HSV DNA collected from Africa, the USA, and South America underwent next-generation sequencing, followed by K-mer based filtering and de novo genomic assembly. Sites of heterogeneity within...
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