Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains.

doi:10.1128/JVI.00416-15

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Article

Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains.

Journal of virology - 1 Jun 2015

Kolb Aaron W, Larsen Inna V, Cuellar Jacqueline A, Brandt Curtis R

Abstract excerpt

UNLABELLED: Herpes simplex virus 2 (HSV-2) is a major global pathogen, infecting 16% of people 15 to 49 years old worldwide and causing recurrent genital ulcers. Little is known about viral factors contributing to virulence, and there are currently only two genomic sequences available. In this study, we determined nearly complete genomic sequences of six additional HSV-2 isolates, using Illumina MiSeq. We report...

Topics

Adolescent
Adult
Animals
Chromosome Mapping
Cluster Analysis
DNA, Viral
Female
Genetic Variation
Genome, Viral
Herpesvirus 2, Human
Humans
Male
Microsatellite Repeats
Middle Aged
Molecular Sequence Data

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Open in PubMed Open full text

Identifiers

PMID: 25855744
DOI: 10.1128/JVI.00416-15
PMCID: PMC4474301

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Phylogeny

Recombination, Genetic

Sequence Analysis, DNA