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Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause

28 May 2024

Abstract excerpt

BACKGROUND: The role of metabolism in the variation of age at menarche (AAM) and age at natural menopause (ANM) in the female population is not entirely known. We aimed to investigate the causal role of circulating metabolites in AAM and ANM using Mendelian randomization (MR). METHODS: We combined MR with genetic colocalization to investigate potential causal associations between 658 metabolites and AAM and...

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Share to Hypothalamic control of reproductive hormones
Share to Menopause: Health Impacts and Treatments
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PMID: 38802955
DOI: 10.1186/s13073-024-01322-7

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