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Article

Lifelong impacts of puberty timing on human plasma metabolic profiles: A metabolome-wide Mendelian randomization study.

Diabetes, obesity & metabolism - 1 Jan 2025

Li Zengjun, Li Xuechao, Fang Si, Liu Dong, Li Fei, Zhu Cairong, Zhao Jian

Abstract excerpt

AIM: The aim was to investigate the causal relationship between puberty timing and plasma metabolites, accounting for birth weight, childhood and adulthood adiposity. MATERIALS AND METHODS: The meta-analysis of genome-wide association studies (GWAS) for puberty timing was extracted from the ReproGen Consortium, involving 329 345 women of European ancestry. Summary data for 174 plasma metabolites were retrieved...

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PMID: 39402736
DOI: 10.1111/dom.16000

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