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Article

Elevated senescence-associated secretory phenotype index in late-life bipolar disorder.

Journal of affective disorders - 1 Sept 2024

Tessema Tselot, Diniz Breno S, Vieira Erica M, Mendes-Silva Ana Paula, Voineskos Aristotle N, Gildengers Ariel G, Husain M Ishrat, Ortiz Abigail, Blumberger Daniel M, Rajji Tarek K, Mulsant Benoit H

Abstract excerpt

BACKGROUND: The senescence-associated secretory phenotype (SASP) is a biomarker index based on the profile of 22 blood proteins associated with cellular senescence. The SASP index has not been assessed in older patients with bipolar disorder (BD). We hypothesized that older adults with BD will have elevated cellular senescence burden as measured by the SASP index. METHODS: We measured the 22 SASP proteins to...

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Identifiers

PMID: 38795779
DOI: 10.1016/j.jad.2024.05.071
PMCID: PMC11209851

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