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Article

Biomarkers of cellular senescence and risk of death in humans.

Aging cell - 1 Dec 2023

St Sauver Jennifer L, Weston Susan A, Atkinson Elizabeth J, Mc Gree Michaela E, Mielke Michelle M, White Thomas A, Heeren Amanda A, Olson Janet E, Rocca Walter A, Palmer Allyson K, Cummings Steven R, Fielding Roger A, Bielinski Suzette J, LeBrasseur Nathan K

Abstract excerpt

A robust and heterogenous secretory phenotype is a core feature of most senescent cells. In addition to mediators of age-related pathology, components of the senescence associated secretory phenotype (SASP) have been studied as biomarkers of senescent cell burden and, in turn, biological age. Therefore, we hypothesized that circulating concentrations of candidate senescence biomarkers, including chemokines,...

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PMID: 37803875
DOI: 10.1111/acel.14006
PMCID: PMC10726868

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