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Prognostic Significance and Biologic Associations of Senescence‐Associated Secretory Phenotype Biomarkers in Heart Failure

29 Aug 2024

Abstract excerpt

BACKGROUND: The role of cellular senescence in human heart failure (HF) remains unclear. The senescence-associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic pathways associated with the SASP in human HF using a plasma proteomics approach. METHODS AND RESULTS: We measured 25 known SASP proteins among 2248 PHFS (Penn HF...

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PMID: 39206715
DOI: 10.1161/jaha.123.033675

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