Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome.

doi:10.1158/1078-0432.CCR-17-1921

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Article

Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2018

Derks Jules L, Leblay Noémie, Thunnissen Erik, van Suylen Robert Jan, den Bakker Michael, Groen Harry J M, Smit Egbert F, Damhuis Ronald, van den Broek Esther C, Charbrier Amélie, Foll Matthieu, McKay James D, Fernandez-Cuesta Lynnette, Speel Ernst-Jan M, Dingemans Anne-Marie C

Abstract excerpt

Purpose: Previous genomic studies have identified two mutually exclusive molecular subtypes of large-cell neuroendocrine carcinoma (LCNEC): the RB1 mutated (mostly comutated with TP53) and the RB1 wild-type groups. We assessed whether these subtypes have a predictive value on chemotherapy outcome.Experimental Design: Clinical data and tumor specimens were retrospectively obtained from the Netherlands Cancer...

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PMID: 29066508
DOI: 10.1158/1078-0432.CCR-17-1921

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