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Article

Clinical significance and mutation analysis of HBsAg and Anti-HBs coexistence in Chronic Hepatitis B.

Virus research - 1 Jul 2026

Zhang Sihang, Lai Xin, Dai Haimei, Li Xiao, Li Xingtong, Liu Fengwei, Zhou Taicheng, Wei Jia

Abstract excerpt

BACKGROUND: The coexistence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) represents an atypical serological profile in chronic hepatitis B (CHB). The clinical significance and molecular characteristics of this double-positive phenomenon remain unclear. This study characterized the clinical and virological features of CHB patients with coexisting HBsAg and anti-HBs and assessed...

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Identifiers

PMID: 42217829
DOI: 10.1016/j.virusres.2026.199758
PMCID: PMC13253202

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AFP

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