Genotyping Hepatitis B virus by Next-Generation Sequencing: Detection of Mixed Infections and Analysis of Sequence Conservation.

doi:10.3390/ijms25105481

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Article

Genotyping Hepatitis B virus by Next-Generation Sequencing: Detection of Mixed Infections and Analysis of Sequence Conservation.

International journal of molecular sciences - 17 May 2024

Dopico Eva, Vila Marta, Tabernero David, Gregori Josep, Rando-Segura Ariadna, Pacín-Ruíz Beatriz, Guerrero Laura, Ubillos Itziar, Martínez Miguel J, Costa Josep, Quer Josep, Pérez-Garreta Javier, González-Sánchez Alejandra, Antón Andrés, Pumarola Tomás, Riveiro-Barciela Mar, Ferrer-Costa Roser, Buti Maria, Rodríguez-Frías Francisco, Cortese Maria Francesca

Abstract excerpt

Our aim was to develop an accurate, highly sensitive method for HBV genotype determination and detection of genotype mixtures. We examined the preS and 5' end of the HBV X gene (5X) regions of the HBV genome using next-generation sequencing (NGS). The 1852 haplotypes obtained were subjected to genotyping via the Distance-Based discrimination method (DB Rule) using two sets of 95 reference sequences of genotypes...

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PMID: 38791519
DOI: 10.3390/ijms25105481
PMCID: PMC11122360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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