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Article

Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex.

Genes - 27 Apr 2024

Voorhies Kirsten, Hecker Julian, Lee Sanghun, Hahn Georg, Prokopenko Dmitry, McDonald Merry-Lynn, Wu Alexander C, Wu Ann, Hokanson John E, Cho Michael H, Lange Christoph, Hoth Karin F, Lutz Sharon M

Abstract excerpt

Depression is heritable, differs by sex, and has environmental risk factors such as cigarette smoking. However, the effect of single nucleotide polymorphisms (SNPs) on depression through cigarette smoking and the role of sex is unclear. In order to examine the association of SNPs with depression and smoking in the UK Biobank with replication in the COPDGene study, we used counterfactual-based mediation analysis...

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Identifiers

PMID: 38790194
DOI: 10.3390/genes15050565
PMCID: PMC11120779

Genes

GRM5

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