Article

Dose-dependent smoking effects on depression inflammatory mediation and substantial prevention potential

2025-11-13

Abstract excerpt

<h4>Background</h4> Depressive disorders represent a leading cause of disability worldwide, yet prevention efforts have had limited success. Smoking is a modifiable risk factor frequently co-occurring with depression, but we lack quantitative evidence on dose-response relationships, cessation timelines, mediating biological pathways, and preventable disease burden. <h4>Methods</h4> We followed 169,741 UK Biobank...

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Literature Corpus work: bdb887ee-7336-57c0-be38-b55e5976db2b
DOI: 10.1101/2025.11.12.25339985

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