Article
GWAS and systems biology analysis of depressive symptoms among smokers from the COPDGene cohort.
Journal of affective disorders - 15 Jan 2019
Heinzman Jonathan T, Hoth Karin F, Cho Michael H, Sakornsakolpat Phuwanat, Regan Elizabeth A, Make Barry J, Kinney Gregory L, Wamboldt Frederick S, Holm Kristen E, Bormann Nicholas, Robles Julian, Kim Victor, Iyer Anand S, Silverman Edwin K, Crapo James D, Han Shizhong, Potash James B, Shinozaki Gen
Abstract excerpt
BACKGROUND: Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. METHODS: Data were from 9716 COPDGene subjects with ≥10 pack-year history. Depression was defined as antidepressant use and/or a HADS depression subscale score ≥8. Non-Hispanic White (6576)...
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