Coupling thermotolerance and high production of recombinant protein by CYR1N1546K mutation via cAMP signaling cascades.

doi:10.1038/s42003-024-06341-z

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Article

Coupling thermotolerance and high production of recombinant protein by CYR1N1546K mutation via cAMP signaling cascades.

Communications biology - 24 May 2024

Ren Haiyan, Lan Qing, Zhou Shihao, Lyu Yilin, Yu Yao, Zhou Jungang, Mo Wenjuan, Lu Hong

Abstract excerpt

In recombinant protein-producing yeast strains, cells experience high production-related stresses similar to high temperatures. It is possible to increase recombinant protein production by enhancing thermotolerance, but few studies have focused on this topic. Here we aim to identify cellular regulators that can simultaneously activate thermotolerance and high yield of recombinant protein. Through screening at...

Topics

Cyclic AMP
Recombinant Proteins
Kluyveromyces
Signal Transduction
Thermotolerance
Mutation
Fungal Proteins
Hot Temperature

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PMID: 38789513
DOI: 10.1038/s42003-024-06341-z
PMCID: PMC11126729

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