Rapid tumor DNA analysis of cerebrospinal fluid accelerates treatment of central nervous system lymphoma.

doi:10.1182/blood.2024023832

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Article

Rapid tumor DNA analysis of cerebrospinal fluid accelerates treatment of central nervous system lymphoma.

Blood - 5 Sept 2024

Gupta Mihir, Bradley Joseph D, Massaad Elie, Burns Evan J, Georgantas N Zeke, Maron Garrett E, Batten Julie M, Gallagher Aidan, Thierauf Julia, Nayyar Naema, Gordon Amanda, Jones SooAe S, Pisapia Michelle, Sun Ying, Jones Pamela S, Barker Fred G, Curry William T, Gupta Rajiv, Romero Javier M, Wang Nancy, Brastianos Priscilla K, Martinez-Lage Maria, Tateishi Kensuke, Forst Deborah A, Nahed Brian V, Batchelor Tracy T, Ritterhouse Lauren L, Iser Florian, Kessler Tobias, Jordan Justin T, Dietrich Jorg, Meyerson Matthew, Cahill Daniel P, Lennerz Jochen K, Carter Bob S, Shankar Ganesh M

Abstract excerpt

ABSTRACT: Delays and risks associated with neurosurgical biopsies preclude timely diagnosis and treatment of central nervous system (CNS) lymphoma and other CNS neoplasms. We prospectively integrated targeted rapid genotyping of cerebrospinal fluid (CSF) into the evaluation of 70 patients with CNS lesions of unknown cause. Participants underwent genotyping of CSF-derived DNA using a quantitative polymerase chain...

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Identifiers

PMID: 38776489
DOI: 10.1182/blood.2024023832
PMCID: PMC11406186

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