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Article

Reliable detection of CNS lymphoma-derived circulating tumor DNA in cerebrospinal fluid using multi-biomarker NGS profiling: insights from a real-world study

9 May 2025

Abstract excerpt

BACKGROUND: Diagnosing primary or secondary CNS lymphoma (CNSL) is a clinical challenge due to the limitations of standard biopsy and imaging procedures despite established guidelines. Therefore, accurate biomarkers and analytical methods that are convenient for practical routine use are needed to diagnose and manage these aggressive lymphomas effectively. We evaluated the utility of minimally invasive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40346678
DOI: 10.1186/s40364-025-00777-z

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