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Analysis of pathogenic variants in BRCA1 and BRCA2 genes using next-generation sequencing in women with triple negative breast cancer from South India.

Molecular biology reports - 1 Apr 2022

Rajagopal Taruna, Seshachalam Arun, Jothi Arunachalam, Rathnam Krishna Kumar, Talluri Srikanth, Venkatabalasubranian Sivaramakrishnan, Dunna Nageswara Rao

Abstract excerpt

BACKGROUND: The frequency of triple-negative breast cancer (TNBC) incidence varies among different populations suggesting the involvement of genetic components towards TNBC development. Previous studies have reported that BRCA1/2 germline mutations confer a lifetime risk of developing TNBC. However, there is hardly any information regarding the common pathogenic variants (PVs) in BRCA1/2 genes that contribute to...

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PMID: 35020120
DOI: 10.1007/s11033-022-07129-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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