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Article

Mixed histiocytic disorders: Nature versus nurture?

British journal of haematology - 1 Jul 2024

McClain Kenneth, Dimitrion Peter

Abstract excerpt

Histiocytic diseases arise from MAPK mutations in myeloid progenitors. Depending on whether the progenitor follows a dendritic cell or macrophage/monocyte lineage the final histology results in Langerhans cell histiocytosis, Rosai-Dorfman disease or Erdheim-Chester disease. Commentary on: Friedman et al. Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic mutations and responses to...

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PMID: 38763166
DOI: 10.1111/bjh.19511

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