Article
Spectrum of histiocytic neoplasms associated with diverse haematological malignancies bearing the same oncogenic mutation.
The journal of pathology. Clinical research - 1 Jan 2021
Kemps Paul G, Hebeda Konnie M, Pals Steven T, Verdijk Robert M, Lam King H, Bruggink Annette H, de Lil Heleen S, Ruiterkamp Bart, de Heer Koen, van Laar Jan Am, Valk Peter Jm, Mutsaers Pim, Levin Mark-David, Hogendoorn Pancras Cw, van Halteren Astrid Gs
Abstract excerpt
Histiocytic disorders are a spectrum of rare diseases characterised by the accumulation of macrophage-, dendritic cell-, or monocyte-differentiated cells in various tissues and organs. The discovery of recurrent genetic alterations in many of these histiocytoses has led to their recognition as clonal neoplastic diseases. Moreover, the identification of the same somatic mutation in histiocytic lesions and...
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